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AG Thedieck: Functional Proteomics of Metabolic Signaling

 

Kathrin Thedieck

 

Affiliated Member of BIOSS - Centre of Biological Signalling Studies

Affiliated Member of ZBSA - Center for Biological Systems Analysis

View Dr. Thedieck's profile at XING.

 

 

 

 

The group of Kathrin Thedieck  analyses the TOR pathway and its role in metabolic processes by means of biochemistry, proteomics and cell biology in human cells and in the genetic model organism C. elegans.
TOR, the target of the anti-cancer drug rapamycin, is deregulated in a large number of tumors and is involved in aging related disorders such as metabolic and neurodegenerative diseases. TOR occurs in two structurally and functionally distinct multiprotein complexes, named TOR complex 1 (TORC1) and TORC2. TORC1, in response to growth factors (insulin), nutrients (amino acids), and energy (ATP), controls growth related processes such as translation, ribosome biogenesis, and autophagy. In contrast to TORC1, TORC2 is rapamycin insensitive and controls spacial growth and migration via the actin cytoskeleton. The Thedieck  lab  analyses the TOR pathway and its role in metabolic processes by means of biochemistry, proteomics and cell biology in human cells and in the genetic model organism C. elegans. We contributed recently to the discovery of a new, inhibitory TORC1 interactor (Thedieck et al. 2007). Currently, several research projects are in progress to elucidate novel links between TOR and its metabolic inputs.

 
Employment/Experience
2001-2002 Diploma Thesis and Postgraduate Scientist, BioVisioN AG, Hannover
2002-2005 PhD Thesis and Postdoc, Div. of Cell and Immune Biology (Prof. J. Wehland and Dr. L. Jänsch), Hemholtz Centre for Infection Research (HZI) and TU Braunschweig
2006-2008 Postdoctoral Fellow, Dept. of Biochemistry (Prof. Michael N. Hall), Biozentrum, University of Basel, Switzerland
2008-present Group Leader Functional Proteomics of Metabolic Signaling, Department for Bioinformatics and Molecular Genetics (Prof. R. Baumeister), University of Freiburg
 
Honors, Awards, and Scholarships
1998-2001 Scholarship from ERASMUS program and the federal state of BW (for ESBS studies)
2002-2005 Georg-Christoph-Lichtenberg Fellowship (for PhD thesis)
2004 Selected Helmholtz delegation member: 18th meeting of Nobel Laureates in Physics
2006/2007 Mentee: Women into Industry program (WIN) of Novartis and the Basel University
2007-2008 PostDoc Fellowship of the Peter und Traudl Engelhorn Stiftung zur Förderung der Biotechnologie und Gentechnik
2009-2010 Schlieben-Lange Fellowship (for habilitation)
2009-2011 2 project grants from the Network of Excellence LifeSpan (EU 6th Framework programme)
2010-2012 project grant of the BIOSS Centre for Biological Signalling Studies
2011-2014 project grant of the BMBF (GerontoSys 2)
 

Publications

Tim O. Lankisch, Jochen Metzger, Ahmed Negm, Katja Voßkuhl, Eric Schiffer, Justyna Siwy, Tobias J. Weismüller, Andrea S. Schneider, Kathrin Thedieck, Ralf Baumeister, Petra Zürbig, Eva M. Weissinger, Michael P. Manns, Harald Mischak, Jochen Wedemeyer (2010). Bile proteomic profiles differentiates cholangiocarcinoma from primary sclerosing cholangitis and choledocholithiasis. Hepatology, 2010 Dec 7.

Kathrin Thedieck and Michael N. Hall (2009). Translational Control by Amino Acids and Energy. The Handbook of Cell Signaling, R. Bradshaw and E. Dennis (editors), 2nd edition, 2009.

Hong Jiang, Eric Schiffer, Zhangfa Song, Jianwei Wang, Petra Zürbig, Kathrin Thedieck, Suzette Moes, Heike Bantel, Nadja Saal, Justyna Jantos, Meiken Brecht, Paul Jenö, Michael N. Hall, Klaus Hager, Michael P. Manns, Hartmut Hecker, Arnold Ganser, Konstanze Döhner, Andrzej Bartke, Christoph Meissner, Harald Mischak, Zhenyu Ju, and K. Lenhard Rudolph (2008). Proteins induced by telomere dysfunction and DNA damage represent biomarkers of human aging and disease. PNAS 2008 Aug 12; 105(32): 11299-304.

Kathrin Thedieck, Pazit Polak, Man Lyang Kim, Klaus D. Molle, Adiel Cohen, Paul Jenö, Cecile Arrieumerlou, Michael N. Hall (2007). PRAS40 and PRR5-Like Protein Are New mTOR Interactors that Regulate Apoptosis. PLoS ONE, Nov 2007, 2(11): e1217. doi:10.1371/journal.pone.0001217

Kathrin Thedieck, Torsten Hain, Brian J. Tindall, Walid Mohamed, Manfred Nimtz, Trinad Chakraborty, Jürgen Wehland and Lothar Jänsch (2006). The MprF protein is required for lysinylation of phospholipids in listerial membranes and confers resistance to cationic antimicrobial peptides (CAMPs) on Listeria monocytogenes. Molecular Microbiology, Dec 2006, Vol 62, p.1325 

 

AG Thedieck

 

AG Thedieck: Functional Proteomics of Metabolic Signaling (2.3.2011)

From left to right: K. Thedieck (groupleader), A. Heberle (internship student), T. Prentzell (diploma student), S. Ruf (PhD student), B. Holzwarth (technician), A. Sonntag (PhD student), A. Thien (PhD student, visiting scientist), L. Maerz (student technician, not on the picture)

 

AG Thedieck too

 

AG Thedieck: Functional Proteomics of Metabolic Signaling (25.5.2011)

Back, from left to right: A. Thien (PhD student, visiting scientist), L. Maerz (student technician), S. Ruf (PhD student), A. Heberle (student technician).
Front, from left to right: K. Thedieck (groupleader), T. Prentzell (diploma student), J. Schwarz (diploma student), A. Sonntag (PhD student). B. Holzwarth (technician, not on the picture).

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