Education and Research

I studied biology at the Georg August University of Göttingen. In 1992 I received my PhD degree (Dr.rer.nat. with honors) in the Department of Developmental Biology. For the next two years I worked as a postdoc in the lab of Prof. Grossbach, Developmental Biology, at the University of Göttingen and until 1995 as a Senior Research Associate at the Institute of Pathology of Prof. Joseph Ilan at the Case Western Reserve University, Cleveland, OH. In 1996 I returned to the University of Göttingen, where I worked in the Department of Developmental Biology as a groupleader and principal investigator of a C. elegans research group. In 2004 I joined the group of Ralf Baumeister as a Senior Scientist (Akademischer Rat) in Freiburg.

Honors and Awards

• 1985-1988: Scholarship of the German National Scholarship Foundation
• 1987: Prize of the Lower Saxony Minister of Science and Arts for excellent studental work in science
• 1989: Member of the 101st Embryology Course Class, Marine Biological Laboratory, Woods Hole, MA. Course Director: Eric H. Davidson
• 1990-1992: Stipend according to the Lower Saxony law for the support of graduate students
• 1994-1996: Research Fellowship of the Deutsche Forschungsgemeinschaft: Gene therapy of cancer by IGF-I antisense RNA expression
• 1998: Participant of the EMBO Practical Course on Molecular, Genetic and Informatic Methods for C. elegans. Course Directors: Alan Coulson and Jonathan Hodgkin
• 1997-1998: DFG grant SCHU 1033 / 2-1: Artificial repression of transcription by triplex-forming RNAs in stable transfected culture cells
• 1998-2000: DFG grant RU 725/1-2 (D. Rudoplph, G. Schmahl, E. Schulze):X-ray microscopical analysis of protein and nucleic acid distributions in eukaryotic cells and chromosomes
• 1998-2004: DFG grant: SCHU 1033 / 1-3: Molecular analysis of the functions of linker histone variants in Caenorhabditis elegans
• 2000-2002: DFG grant SFB271 Project A14: Molecular analysis of the morphogenesis of the C. elegans dauer larva
• 2000-2002: Member of the Sonderforschungsbereich (SFB) 271: 'Molecular genetics of morphoregulatory processes'
• 2000-today: Member of international program 'Masters Molecular Biology' at the University of Göttingen
• 2000-today: Member of DFG Graduiertenkolleg 242 'Molecular genetics of Development' at the University of Göttingen

Memberships in Scientific and professional societies

Member of the German National Scholarship Foundation since 1987

Publications
Novel roles of C. elegans heterochromatin protein HP1 and linker histone in the regulation of innate immune gene expression.
Studencka M, Konzer A, Moneron G, Wenzel D, Opitz L, Salinas-Riester G, Bedet C, Krüger M, Hell SW, Wisniewski JR, Schmidt H, Palladino F, Schulze E, Jedrusik-Bode M
Mol Cell Biol. 2011 Nov 14;
PMID: 22083954 [PubMed - as supplied by publisher]

SnAvi - a new tandem tag for high-affinity protein-complex purification.
Schäffer U, Schlosser A, Müller KM, Schäfer A, Katava N, Baumeister R, Schulze E.
Nucleic Acids Res. 2010 Jan 4. [Epub ahead of print]
PMID: 20047968 [PubMed - indexed for MEDLINE] |

G1 phase-dependent nucleolar accumulation of human histone H1x.
Stoldt S, Wenzel D, Schulze E, Doenecke D, Happel N
Biol Cell. 2007 Oct;99(10):541-52
PMID: 17868027 [PubMed - indexed for MEDLINE]

Linker histone HIS-24 (H1.1) cytoplasmic retention promotes germ line development and influences histone H3 methylation in Caenorhabditis elegans.
Jedrusik MA, Schulze E
Mol Cell Biol. 2007 Mar;27(6):2229-39
PMID: 17210650 [PubMed - indexed for MEDLINE]

Characterisation of human histone H1x.
Happel N, Schulze E, Doenecke D
Biol Chem. 2005 Jun;386(6):541-51
PMID: 16006241 [PubMed - indexed for MEDLINE]

Analysis of germline chromatin silencing by double-stranded RNA-mediated interference (RNAi) in Caenorhabditis elegans.
Jedrusik MA, Schulze E
Methods Mol Biol. 2004;254:35-48
PMID: 15041754 [PubMed - indexed for MEDLINE]

Functional analysis of the single calmodulin gene in the nematode Caenorhabditis elegans by RNA interference and 4-D microscopy.
Karabinos A, Büssing I, Schulze E, Wang J, Weber K, Schnabel R
Eur J Cell Biol. 2003 Nov;82(11):557-63
PMID: 14703012 [PubMed - indexed for MEDLINE]

In vivo and in vitro evidence that the four essential intermediate filament (IF) proteins A1, A2, A3 and B1 of the nematode Caenorhabditis elegans form an obligate heteropolymeric IF system.
Karabinos A, Schulze E, Schünemann J, Parry DA, Weber K
J Mol Biol. 2003 Oct 17;333(2):307-19
PMID: 14529618 [PubMed - indexed for MEDLINE]

The maintenance of neuromuscular function requires UBC-25 in Caenorhabditis elegans.
Schulze E, Altmann ME, Adham IM, Schulze B, Fröde S, Engel W
Biochem Biophys Res Commun. 2003 Jun 6;305(3):691-9
PMID: 12763049 [PubMed - indexed for MEDLINE]

Telomeric position effect variegation in Saccharomyces cerevisiae by Caenorhabditis elegans linker histones suggests a mechanistic connection between germ line and telomeric silencing.
Jedrusik MA, Schulze E
Mol Cell Biol. 2003 May;23(10):3681-91
PMID: 12724425 [PubMed - indexed for MEDLINE]

The Caenorhabditis elegans ortholog of human PHF5a shows a muscle-specific expression domain and is essential for C. elegans morphogenetic development.
Trappe R, Schulze E, Rzymski T, Fröde S, Engel W
Biochem Biophys Res Commun. 2002 Oct 4;297(4):1049-57
PMID: 12359262 [PubMed - indexed for MEDLINE]

Expression profiles of the essential intermediate filament (IF) protein A2 and the IF protein C2 in the nematode Caenorhabditis elegans.
Karabinos A, Schulze E, Klisch T, Wang J, Weber K
Mech Dev. 2002 Sep;117(1-2):311-4
PMID: 12204276 [PubMed - indexed for MEDLINE]

A novel linker histone-like protein is associated with cytoplasmic filaments in Caenorhabditis elegans.
Jedrusik MA, Vogt S, Claus P, Schulze E
J Cell Sci. 2002 Jul 15;115(Pt 14):2881-91
PMID: 12082149 [PubMed - indexed for MEDLINE]

A single histone H1 isoform (H1.1) is essential for chromatin silencing and germline development in Caenorhabditis elegans.
Jedrusik MA, Schulze E
Development. 2001 Apr;128(7):1069-80
PMID: 11245572 [PubMed - indexed for MEDLINE]

The histone H1 genes of the dipteran insect, Chironomus thummi, fall under two divergent classes and encode proteins with distinct intranuclear distribution and potentially different functions.
Trieschmann L, Schulze E, Schulze B, Grossbach U
Eur J Biochem. 1997 Nov 15;250(1):184-96
PMID: 9432008 [PubMed - indexed for MEDLINE]

The expression of the imprinted genes H19 and IGF-2 in choriocarcinoma cell lines. Is H19 a tumor suppressor gene?
Lustig-Yariv O, Schulze E, Komitowski D, Erdmann V, Schneider T, de Groot N, Hochberg A
Oncogene. 1997 Jul 10;15(2):169-77
PMID: 9244352 [PubMed - indexed for MEDLINE]

Suppression of insulin-like growth factor type I receptor by a triple-helix strategy inhibits IGF-I transcription and tumorigenic potential of rat C6 glioblastoma cells.
Rininsland F, Johnson TR, Chernicky CL, Schulze E, Burfeind P, Ilan J
Proc Natl Acad Sci U S A. 1997 May 27;94(11):5854-9
PMID: 9159164 [PubMed - indexed for MEDLINE]

The Vertebrate Linker Histones H10, H5, and H1M Are Descendants of Invertebrate "Orphon" Histone H1 Genes
Schulze E, Schulze B
J Mol Evol. 1997 Apr;44(4):466-7
PMID: 9089088 [PubMed - as supplied by publisher]

Potential triple helix-mediated inhibition of IGF-I gene expression significantly reduces tumorigenicity of glioblastoma in an animal model.
Shevelev A, Burfeind P, Schulze E, Rininsland F, Johnson TR, Trojan J, Chernicky CL, Hélène C, Ilan J, Ilan J
Cancer Gene Ther. 1997 Mar-Apr;4(2):105-12
PMID: 9080119 [PubMed - indexed for MEDLINE]

Developmentally imprinted genes as markers for bladder tumor progression.
Cooper MJ, Fischer M, Komitowski D, Shevelev A, Schulze E, Ariel I, Tykocinski ML, Miron S, Ilan J, de Groot N, Hochberg A
J Urol. 1996 Jun;155(6):2120-7
PMID: 8618347 [PubMed - indexed for MEDLINE]

The vertebrate linker histones H1 zero, H5, and H1M are descendants of invertebrate "orphon" histone H1 genes.
Schulze E, Schulze B
J Mol Evol. 1995 Dec;41(6):833-40
PMID: 8587127 [PubMed - indexed for MEDLINE]

The expression of the imprinted H19 and IGF-2 genes in human bladder carcinoma.
Elkin M, Shevelev A, Schulze E, Tykocinsky M, Cooper M, Ariel I, Pode D, Kopf E, de Groot N, Hochberg A
FEBS Lett. 1995 Oct 23;374(1):57-61
PMID: 7589512 [PubMed - indexed for MEDLINE]

Insect proteins homologous to mammalian high mobility group proteins I/Y (HMG I/Y). Characterization and binding to linear and four-way junction DNA.
Claus P, Schulze E, Wiśniewski JR
J Biol Chem. 1994 Dec 30;269(52):33042-8
PMID: 7806532 [PubMed - indexed for MEDLINE]

Structurally divergent histone H1 variants in chromosomes containing highly condensed interphase chromatin.
Schulze E, Nagel S, Gavenis K, Grossbach U
J Cell Biol. 1994 Dec;127(6 Pt 2):1789-98
PMID: 7806560 [PubMed - indexed for MEDLINE]

DNA binding and nuclear translocation of insect high-mobility-group- protein-1 (HMG1) proteins are inhibited by phosphorylation.
Wiśniewski JR, Schulze E, Sapetto B
Eur J Biochem. 1994 Oct 15;225(2):687-93
PMID: 7957184 [PubMed - indexed for MEDLINE]

High affinity interaction of dipteran high mobility group (HMG) proteins 1 with DNA is modulated by COOH-terminal regions flanking the HMG box domain.
Wiśniewski JR, Schulze E
J Biol Chem. 1994 Apr 8;269(14):10713-9
PMID: 8144661 [PubMed - indexed for MEDLINE]

Structural and functional differences between histone H1 sequence variants with differential intranuclear distribution.
Schulze E, Trieschmann L, Schulze B, Schmidt ER, Pitzel S, Zechel K, Grossbach U
Proc Natl Acad Sci U S A. 1993 Mar 15;90(6):2481-5
PMID: 8460162 [PubMed - indexed for MEDLINE]

Insect proteins homologous to mammalian high mobility group protein 1. Characterization and DNA-binding properties.
Wiśniewski JR, Schulze E
J Biol Chem. 1992 Aug 25;267(24):17170-7
PMID: 1512255 [PubMed - indexed for MEDLINE]